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"That's a real small fraction of the size of these medical device markets that we're talking about," he said

Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits hyperglycemia-induced apoptosis in myocytes by suppressing receptor for advanced glycation end products expression

Future work may adapt this strategy into mRNA-based therapeutics or pegylated protein formulations with improved stability and targeted delivery

Its development program was halted after Phase 2b trials, and it never reached approval as an obesity medication

As a potential confounding factor, we could not entirely exclude the possibility of lifestyle changes accompanying medication adjustments, and the retrospective nature of the study made it challenging to minimize sources of bias