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10.3389/fpls.2017.00285 Front

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More recently, however, an animal study based on a tandem stenosis mouse model showed the ability of SGLT2is to stabilize atherosclerotic plaques, with increased fibrosis, augmented collagen accumulation, and significant upregulation of the expression of vasculoprotective NADPH oxidase 4 [18]

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2.11 Mitochondrial morphological analysis by confocal microscopy A375 human melanoma cells were seeded in a 4-chamber plate at a density of 1.5 10 4 cells/well in 500 l culture medium in a 5% CO 2 incubator overnight at 37 C

187,188 Since 2007, genome-wide association studies (GWAS) and next-generation sequencing (NGS) have identified different genetic variants associated with IR, including PPAR , IRS1 , IGF1 , NAT2 , KLF14 , GCKR , FTO , TCF7L2 , TMEM163 , MC4R , SC4MOL , TCERG1L , and ARL15 184,189,190 by influencing insulin action via different regulatory mechanisms