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Initial combination therapy with canagliflozin plus metformin versus each component as monotherapy for drug-nave type 2 diabetes

Normally, this compound is neutralized by glutathione, a powerful antioxidant

Zhilyaeva TV, Piatoikina AS, Bavrina AP, et al

However, because IKE decreased cystine uptake and GSH/GSSG levels and increased ROS, yet did not induce a marked increase in cell death when used alone, our data suggests that a dominant ferroptotic cell death induction is unlikely in our experimental settings