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doi: 10.1126/science.7046051
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High levels of ROS in the tumor microenvironment due to oxidative stress stimulates the cancer cells, which begins to secrete the angiogenic modulators [53]
Multi-method triangulation - combining supply-side, demand-side, macro, primary, and secondary sources - ensures the reliability and actionability of findings
Under physiological conditions, more than 98% of the total GSH pool exists in the reduced form, thereby shaping cellular redox potential and influencing proliferation, differentiation, and cell death 5 .Although the GSH/GSSG ratio has long been regarded as an indicator of cellular redox status, recent live-cell studies using genetically encoded redox sensors indicate that increases in GSSG are typically transient and compartmentalized rather than sustained intracellular accumulations 6,7
