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TB-500 is under FDA advisory review in July 2026, and FDA staff documents recommend caution because human safety and effectiveness data are limited

This is normal the largest jump occurs when going from a GH-deficient state to optimized levels

A separate Phase 2 trial also published in The New England Journal of Medicine in 2023 evaluated retatrutide in adults with type 2 diabetes, reporting meaningful reductions in HbA1c alongside weight loss, with hypoglycaemia rates that were low in the absence of insulin or sulfonylurea co-administration