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Risk factor for toxic liver injury

There have been postmarketing reports of fatal events of ketoacidosis in patients with type 2 diabetes mellitus using SGLT2 inhibitors, including dapagliflozin

Haematological improvement typically occurs within days to weeks, with reticulocyte counts rising as the marrow responds

This proposed mechanism may highlight MT-1 as part of broader peptide-related pathways in controlling immune-driven inflammation in neural and ocular tissues