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As a class, however, these agents work similarly where they mimic the structure of GLP-1 in vivo , and thus, can bind the GLP-1R, but are not subject to degradation by DPP-4
Much efforts have been invested in peptide and peptidomimetic chemistries 6,7,8,9,10,11 to address those weaknesses in the hope of finding an alternative to peptides and recently foldamer research has attracted much interest 12,13,14,15
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The SOD1 G93A mutation results in its accumulation within axons and significantly impedes mitochondrial trafficking