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However, if the accumulation of acetaldehyde occurs faster than the action of aldehyde dehydrogenase (such as during a heavy drinking session), this can result in a bad hangover
Interpretation should consider: Symptoms CBC (especially if basophilia, leukocytosis, etc.) Liver function tests Renal function Inflammatory markers Even high serum cobalamin levels can be accompanied by functional deficiency Suggested Workup for Unexplained High B12 : Repeat B12 measurement off supplements Check: Liver enzymes CBC with differential Serum creatinine Holotranscobalamin active fraction of vitamin B12, bound to TCB II 8 Consideration of myeloproliferative neoplasm workup if hematologic abnormalities are present Imaging if malignancy suspected (e.g., abdominal imaging if liver pathology or malignancy is suspected) In summary, while elevated B12 is most often benign and related to supplementation or liver/renal dysfunction, it is essential to rule out underlying hematologic malignancy or solid organ cancer when unexplained or accompanied by abnormal clinical or laboratory findings
It is brought on, in most cases, by changes in hormones that are flowing through the body and in cell growth
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Chapter 36: Megaloblastic anemias: disorders of impaired DNA synthesis by Ralph Carmel
Kraft, V
