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Recently, a study further revealed that IGF1-induced BNIP3 expression requires NRF2 to act through downstream transcriptional factors HIF-1 and NRF1 (Riis et al., 2020)

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However, when assessing EWcp/UCN1 dynamics in chronic alcohol consumption, we observed significant Ucn1 downregulation whereas the peptide content did not change, suggesting disrupted UCN1 turnover