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The retinoid comparison makes GHK-Cu discontinuation appear favorable since copper peptide cessation typically produces gradual benefit decline without rebound worsening or dramatic rapid reversal

Thiboutot et al

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Copper (I) oxide causes dose-dependent decrease in the viability of airway epithelial cells by impairing the activities of catalase and glutathione reductase , generating reactive oxygen species , and increasing the levels of 8-isoprostane and the ratio of oxidized glutathione