For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM, that explain poor responders to their medications. For now, the mechanism driving GLP-1 resistance remains unresolved, but it is likely complex and multifactorial, Gloyn said
GLP-1RAs are now a mainstay in frontline care for T2D, obesity, and related conditions
Participants consumed excess sodium, saturated fat, and calories
This overall average calorie intake, the paper notes, exceeds expert recommendations for individuals on GLP-1RAs (typically 1,2001,500 kcal/day for females and 1,5001,800 kcal/day for males)
There are a whole class of medications that are insulin sensitizers, so perhaps we can develop medications that will allow people to be sensitized to GLP-1s or find formulations of GLP-1, like the longer-acting versions, that avoid the GLP-1 resistance. Anna Gloyn A key function of GLP-1 and drugs that mimic it is to slow the passage of food through the stomach, known as gastric emptying, which helps with both glucose regulation and weight loss
Leggio says that it is important to emphasize that these are not bad behaviors or bad habits but chronic medical conditions, like diabetes, hypertension, or rheumatoid arthritis
