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Results May Be Subtleor Nonexistent Even among users who report overall wellness benefits, skin improvements are often minimal or hard to detect

They are also being explored for off-label uses such as CKD, MASLD, substance use disorders, chronic pain, neurodegenerative disorders, and PCOS

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Pathological expansion and dysfunction of EAT promote AF through paracrine and vasocrine secretion of pro-inflammatory and pro-fibrotic cytokines, release of extracellular vesicles carrying arrhythmogenic cargo, direct infiltration, and modulation of local electrophysiology and autonomic signaling, thereby creating a substrate for atrial cardiomyopathy, fibrosis, electrical remodeling, and AF initiation/persistence