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We counter that the only piece of evidence that at first sight raises a question mark over the cardiovascular benefit of pioglitazone is the primary composite endpoint in the PROactive randomised controlled trial, and we have argued that this endpoint is unreliable

Over time, the pancreas may struggle to keep up with the heightened demand for insulin, causing further elevation of blood sugar levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.West N.J., Thorpe M

This results in hormonal imbalances and causes the ovaries to overproduce androgens

The incubated culture was poured into the corresponding petri plates with solidified agar, and the antifungal present in the samples was allowed to diffuse out into the medium and interact in a plate that had just been seeded with the test organisms

This happens because the body has trouble regulating blood flow and blood pressure, leading to an abnormal rise in heart rate