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Resistance to paclitaxel-based therapies is the primary reason this malignancy ranks as the leading cause of cancer-related mortality in men and the second highest cause in women (Park et al., 2016

In 1956, Laisdell first applied rubber band ligation (RBL) to hemorrhoids

NO pathway and FAK pathway for vascular response due to injury Why this matters: When injuries occur or repair is needed, decreasing inflammation and formation of new blood vessels is required to help the tissue heal

Step back if GI side effects become intense

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