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In the body (gut and pancreas): Help the pancreas release insulin when blood sugar is high Stop the liver from making too much sugar Slow down how fast your stomach empties so you feel full longer In the brain: GLP-1 receptors are also found in the brain, in areas that control hunger, reward, and emotions, such as the hypothalamus, VTA, and amygdala

Preliminary data point toward beneficial effects of GIP agonism, as reported in findings from the SURPASS program that tirzepatide reduced UACR and slowed down eGFR declined in comparison with both placebo (53) and comparator drugs including insulin glargine (74, 75)

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Support from mental health professionals can help navigate these identity transitions smoothly

Studies on other peptides of similar size suggest that enzymatic degradation can reduce bioavailability by 50-80% even before accounting for barrier permeability limitations

Nat Neurosci 1998, 1: 714719