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This is the most speculative of the three pathways - direct human evidence is limited - but it is the rationale most often given for pairing MOTS-c with retatrutide specifically rather than with a slower-deficit compound

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Mitochondrial catalase suppresses naturally occurring lung cancer in old mice

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Cellular studies have indicated that IGF-1 enhances mRNA expression and protein levels in affected brain regions, thereby bolstering cellular responses to brain injury in neurons and astrocytes [207]