Some clinicians extend each step to six or eight weeks, allowing the body more time to adapt
By addressing these pathways simultaneously, retatrutide is hypothesised to achieve greater efficacy in reducing body weight and improving cardiometabolic markers than single or dual receptor agonists
Tirzepatide adds a second mechanism: it also activates the GIP (glucose-dependent insulinotropic polypeptide) receptor, the original incretin identified in the 1970s
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