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The control group will receive semaglutide (0.25 mg weekly) plus sham-taVNS, with electrodes attached to the bilateral auricular scapha at 4/20 Hz for 30 min, twice daily

The recombinant FhGST-S1 enzyme was shown to be active, following the conjugation of substrates 1-chloro-2,4-dinitrobenzene (CDNB) and reduced glutathione according to an adaptation of the method described previously 25

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Its primary mechanism involves activating hepatocyte growth factor (HGF) and c-Met signaling, which plays crucial roles in neuronal growth and synaptic formation