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From a management perspective, with the necessity of glucose-lowering medications like metformin or basal insulin in populations with T2DM complications, 61 combination products with routine injections or basal insulin may offer compliance advantages, simpler titration strategies (adjusting to maximum maintenance dose only once), and lighter economic burdens

Why doubling works as an escalation strategy The dose steps in the retatrutide schedule roughly double at each level: 2mg to 4mg to 8mg, with the final step from 8mg to 12mg being a 50% increase

TRIUMPH-4 (Phase 3, 68 weeks) 12mg dose: 28.7% weight loss (~71 lbs / 32 kg average) 9mg dose: 26.4% weight loss (~64 lbs / 29 kg average) Patients also saw 76% reduction in knee osteoarthritis pain Blood pressure reduced by 14 mmHg on average Source: ClinicalTrials.gov (TRIUMPH-4, NCT05931367) The TRIUMPH Phase 3 program includes 4 trials studying retatrutide for obesity, type 2 diabetes, and cardiovascular outcomes

Patients receiving semaglutide also achieved a whopping 12.5% reduction in their total body weight over the 72-week study period

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