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, 31 showing no change in GPx activity in the early phase, but a decrease in GPx in chronic inpatients and during acute relapse

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In terms of adverse effects, statins reduced stem cells osteogenic and chondrogenic differentiation potential and enhanced cell senescence and apoptosis, as shown through p16 (CDKN2A), p53 (TP53) and caspase 3, 8 and 9 upregulation