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AASLD 2017 Current Status of Pharmacologic Treatments for NASH No approved therapies for NASH Currently available therapeutics with (some) proven efficacy Vitamin E Pioglitazone NASH: targets for therapeutics Endpoints for clinical trials Disease Activity (steatohepatitis) = NAFLD Activity Score (NAS) Disease Progression = Fibrosis Stage Clinical outcomes : Cirrhosis (MELD, Portal hypertension), Liver-related outcome, death Adapted from Konerman MA

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In CarnoSyn beta-alanine, one of its primary mechanisms of action is its ability to enhance intracellular buffering capacity, which results in a greater tolerance for sustained anaerobic activity

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Prescribing decisions are made solely by the treating clinician