Serious adverse effects requiring clinical vigilance include: Lactic acidosis : A rare but potentially fatal complication of metformin, particularly in patients with renal impairment (eGFR 10%), symptomatic hyperglycemia, diagnostic uncertainty, or recurrent hypoglycemia
In addition, Bazzani et al
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Brain Dev 30:3142 Januszewicz E, Bekisz M, Mozrzymas JW, Nalecz KA (2010) High affinity carnitine transporters from OCTN family in neural cells
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