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The intervention showed significant effects, with the EPA group experiencing fewer monthly migraine days, reduced usage of headache medication, and improvements in headache severity (VAS score), disability (MIDAS score), anxiety and depression (HADS score), and quality of life (MSQ score)

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Consistent with these mechanisms, according to the included studies L-carnitine supplementation was associated with lower MDA levels indicating reduced lipid peroxidation and higher SOD and GSH-Px activities which underscores its antioxidant effect in patients with CAD

Quercetin exerts neuroprotective effects through the upregulation of p-Akt expression, downregulation of p-ASK1, p-JNK3, and cleaved caspase-3 expression, and inhibition of neuronal apoptosis (Pei et al., 2016)

2.4 Phosphoglycerate dehydrogenase Van Nyen T, et al

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