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Interestingly, GSTO1 polymorphisms and decreased expression have been implicated in several pathological conditions such as Parkinsons and Alzheimers disease 7
Tirzepatides activation of the GIP and GLP-1 receptors in the pancreas results in increased insulin release and improved blood sugar control [2, 3]
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One method leverages hydrazine chemistry and peptide coupling, where the side chain of the aza-amino acid is built on a hydrazine derivative before coupling with a proteogenic amino acid (Scheme a)
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