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Baseline characteristics play a significant role: Starting weight and BMI : Individuals with higher baseline body weight may experience more absolute weight loss initially Metabolic rate : Basal metabolic rate varies with age, sex, muscle mass, and genetic factors Insulin resistance severity : Those with greater insulin resistance may respond differently Concurrent medications : Some drugs (e.g., corticosteroids, certain antipsychotics) may counteract weight loss Lifestyle factors are equally important: Dietary adherence : Calorie intake and nutritional quality significantly impact results Physical activity levels : Regular exercise enhances weight loss and improves metabolic health Sleep quality : Poor sleep is associated with weight gain and reduced treatment efficacy Stress management : Chronic stress and elevated cortisol can impede weight loss Treatment-related factors include: Dose achieved : Higher doses (14 mg) generally produce greater weight loss than lower doses Treatment duration : Longer treatment periods typically yield more substantial results Tolerability : Gastrointestinal side effects may limit dose escalation in some patients Adherence : Consistent daily dosing is essential for optimal outcomes Additionally, underlying medical conditions such as hypothyroidism, polycystic ovary syndrome, or other endocrine disorders may influence weight loss velocity

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