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Nature 526:719722

10.1016/s0928-4257(99)00123-0 [DOI] [PubMed] [Google Scholar] Skorjanec S., Dolovski Z., Kocman I., Brcic L., Blagaic Boban A., Batelja L., et al

Consider B 12 supplementation without testing in asymptomatic patients with risk factors for B 12 deficiency (see Table 1: Patient Risk Factors Associated with B 12 Deficiency)

Get it wrong, and you could compromise the concentration, leading to skewed data and wasted resources

Golombek and Rosenstein, 2010

Another recent study reported that chronic disruption of circadian rhythms by a 12-h phase advance every 5 days for 7 weeks prior to MCAO increased infarct size in male and female Sprague Dawley rats