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In a field where definitive long-term trials are expensive, messy, and hard to run well, many researchers gradually lowered the bar for what counted as "good enough" evidence
No patients had a history of mental disorders including alcohol abuse and intake of antidepressants or other psychotropic drugs
SILY alone or co-administered with SERT also mitigated the decrease in self-grooming behaviour induced by DEX
10.1074/jbc.RA118.005628 251 ThompsonK
KLOW uses the same base and adds KPV, extending the formulation into KPV-related inflammatory signaling, peptide transport, and epithelial-barrier research
However, efficacy against severe disease does appear more durable, with vaccines leading to a ~90% reduction in severe disease at 5 months postvaccination [30, 33]
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