Some women are more sensitive to side effects during menopause, so slower titration may help
504,505,506 GLP-1 enhances the insulin signaling pathway in the liver by activating the GLP-1R, especially through the phosphorylation of insulin receptor substrates and the activation of the PI3K/Akt signaling pathway, thereby increasing hepatic insulin sensitivity, facilitating glucose uptake and utilization, and reducing hepatic gluconeogenesis
Side-effect management is part of that conversation because nausea, constipation, reflux, and fatigue can all interfere with eating enough protein and maintaining strength
doi: 10.1007/BF00274797 26 DhanvantariSSeidahNGBrubakerPL
Semaglutide can make some people feel tired, especially during the first few weeks of treatment or after a dosage increase
High-satiety foods are those high in protein or in fibre, while low cholesterol foods are those low in saturated fats