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However, a blanket recommendation has not been made in clinical guidelines as there are needs for stronger evidence and determinations of effective doses and specific patient populations that might benefit (Varadharaj et al., 2017)

Immune cells, particularly CD4+ and CD8+ T cells, depend on sufficient arginine concentrations to maintain effector functions

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All patients were in the maintenance phase of chemotherapy and were treated with methotrexate and 6-mercaptopurine

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