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In the mechanistic explanation of disease networks, cellular signal transduction is effectively depicted with causal knowledge such as kinase-transcription factor (TF) and TF-target interactions (Liu et al., 2019

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[DOI] [PubMed] [Google Scholar] 68.Strinic D., Belosic Halle Z., Luetic K., Nedic A., Petrovic I., Sucic M., Zivanovic Posilovic G., Balenovic D., Strbe S., Udovicic M., et al

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Beta-sheet-prone sequences are also at higher risk because beta-sheet structures naturally self-associate into larger aggregates