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It plays a crucial role in controlling blood sugar levels and lowering the risk of cardiovascular complications in individuals with both type 2 diabetes and heart disease

The majority of gastrointestinal adverse events occurred during the titration phase of tirzepatide

Context for confounding and differential diagnosis: SGLT2 inhibitors are known to increase genital mycotic infection risk, including vulvovaginal candidiasis, and real-world studies demonstrate clinically significant vaginitis incidence in usersmaking SGLT2 exposure a critical confounder when patients attribute yeast infections to semaglutide

Nat Rev Dis Primers 2:1604516045 Hu H, Tian M, Ding C, Yu S (2018) The C/EBP Homologous Protein (CHOP) Transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection

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Chaves E, Jeffrey DT, Williams DR