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Chang PLoS ONE.2012

Several enzymes involved in ATP production contain Fe-S clusters in the active site and are subject to similar inactivation by superoxide, including oxoglutarate dehydrogenase of the tricarboxylic acid cycle, as well as ETC complexes IIII

In absolute terms, tirzepatide users lost an average of 22.8kg (about 50 pounds) compared to 15.0kg (about 33 pounds) with semaglutide