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Indirect effects An indirect pathway for GLP-1RAs to mediate risk for PDAC is via acute or chronic pancreatitis, which are risk factors for PDAC 24,25

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The dosing structures are fundamentally different because each peptide has a different receptor profile, different potency per milligram, and different pharmacokinetic properties

Interestingly, exenatide in the LS does not impair anxiety-like behaviors or operant responding, which are key functions for cells within this region that indicate a fine tuning of GLP-1R action in this region

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