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They may also affect the cells involved in fibrosis, the process through which repeated liver damage produces scar tissue

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However, the relationship between ferroptosis and necroptosis remains controversial, and the mediator that triggers both pathways remains unknown

In ATTAIN-1, nausea occurred in 28.9% to 35.9% of orforglipron-treated participants versus 10.4% with placebo, while vomiting was reported in 13.0% to 24.0% versus 4.0% with placebo