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Lifestyle Choices: Smoking, excessive alcohol use, or exposure to pollutants

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10 Women with clinical manifestations of androgen excess such as hirsutism, adult acne, irregular menses, and acanthosis nigricans should undergo a laboratory workup for hyperandrogenemia

A reduction in circumference appears within about 7 days, and the incidence of clinical swelling is below 5%

Laugier-hunziker syndrome: an uncommon cause of oral pigmentation and a review of the literature