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NLRP3/cryopyrin is necessary for interleukin-1 (IL-1) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury

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These authors make the point that genetic effects often appear to be greater in males, perhaps related to their tendency to higher UA concentrations

The most effective approach combines strategic supplementation with intentional food choices that maximize nutrient density per calorie

These findings suggest that, beyond the substrate-energy dimension, sulfur-containing amino acid-related metabolites can also regulate macrophage functional states in chronic inflammatory environments by affecting processes such as oxidative stress, protein modification, and mitochondrial homeostasis