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While rosuvastatin is not a major CYP3A4 substrate, P-gp activity may still modestly reduce its hepatic exposure

15 minutes after an intravenous infusion of 2 g of glutathione, the average concentration of glutathione in the blood is 444 mmol/l (the average physiological concentration of glutathione in the blood is 6.9 mmol/l)

These findings substantiate the therapeutic merit of ACSL4 pathway modulation in OA intervention

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