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The release of GABA into the synaptic cleft is triggered by depolarization of the presynaptic membrane

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established an animal model of lung injury from hypobaric hypoxia in a high altitude condition, which involved exposing SD rats to hypoxia at an altitude of 6000 m, with an ascent rate of 10 m/s, and continuous exposure to hypoxia for 3 days (Table 1

J Biol Chem 2004;279:55008-16

D is the 3.2 mg KLOW dose, M is the vials total 80 mg, and V_draw is the selected draw volume in mL: V water = V draw M D Worked example: 3.2 mg total KLOW in a 0.2 mL, or 20-unit, draw

They may retain some pharmacological activity and can sometimes be more toxic than the parent compound