Most people finish their protocol or transition to a maintenance schedule
Following treatment, the vitamin B12 status of herbivores should be maintained by dietary supplementation with cobalt
Extended follow-up studies would identify any delayed adverse effects and establish whether therapeutic benefits persist, diminish, or require continued treatment for maintenance
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While this methylation reaction was historically considered a relatively minor metabolic pathway for nicotinamide clearance, research over the past decade has revealed that NNMT plays a surprisingly important and previously underappreciated role in cellular energy metabolism, NAD+ homeostasis, adipocyte biology, and whole-body metabolic regulation
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