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Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis

This structural damage causes further mitochondrial failure and even more ROS leakage, creating a continuous "doom loop" of profound energy depletion, systemic inflammation, and the hallmark symptom of post-exertional malaise (PEM)

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Low NAD+ levels can lead to several conditions including metabolic diseases, cancer, aging, and neurodegenerative disorders

At the imaging level, metabolic imaging modalities such as positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and emerging techniques like magnetic resonance spectroscopic imaging (MRSI) are being employed for non-invasive assessment of tumor metabolic activity and mitochondrial function [141, 142]