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According to GRADE methodology, evidence for improvements in blood urea nitrogen, total cholesterol, and LDL-C was of moderate quality, whereas data on serum creatinine, UACR, fasting glucose, and HbA1c were rated low quality (248)

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These findings suggest that, from a clinical standpoint, clinicians should not expect substantial effects of GLP-1-based therapies on lipid levels or BP

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