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516 Furthermore, TGR5 promotes the polarization of macrophages from a pro-inflammatory M1 state to an anti-inflammatory M2 state, positioning certain bile acids as intrinsic regulators of macrophage polarization and liver repair

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Its primary roles are: Removal of oxidative stress Promotion of liver detoxification Immune system support Boost for other antioxidants like vitamin C and Glutathione exists in reduced glutathione (GSH) and disulfide (GSSG) forms

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Owing to their ability to self-renew and maintain tissue homeostasis over prolonged periods, MSCs are particularly susceptible to cumulative environmental stress

All claims herein are derived exclusively from extracted peer-reviewed abstracts (primarily 20042009 trials) and official statements