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Rinaman said, It could be that were underestimating the amount to which these drugs penetrate just by virtue of the way those experiments are done and the non-enhanced visualization of the receptors. There are various reasons that the experiments using the fluorescent tags may underestimate the extent to which the GLP-1R agonists reach targets in the brain, she added

a Brain sections stained with cresyl violet were shown on the left

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After 12 weeks, she sees slight improvement in face/cheeks but not dramatic

The RT-qPCR results also indicated that the inflammatory factors IL-6 and TNF- increased significantly on day 1, but there were no significant differences compared to the NC group on days 2 and 3 (Fig