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What is still being studied Open scientific questions Long-term safety beyond the trial duration, weight regain after discontinuation, comparative effectiveness against Tirzepatide head-to-head, and response variability across populations are all areas where evidence is still maturing

and the Van Groningen signatures, derived from conventional serum-grown cell lines in vitro 13

Elevated insulin-like growth factor-1 in Cushings disease

Commonly studied for its role in tissue repair, angiogenesis, and cellular regeneration pathways

If injections are not an option Only choice in Canada: Rybelsus (3, 7 or 14 mg daily)

Markers of insulin sensitivity improved, fasting glucose trended lower, and A1C remained stable or decreased despite no pre-existing elevation