Injections may provide faster and more direct absorption, while troches offer ease of use and may be preferable for individuals uncomfortable with needles
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By comparison, oral formulations result in slower systemic drug delivery but offer significant advantages for IBD therapy, including localized colon targeting, non-invasive administration, and greater patient compliance [48,49,50]
This can often deliver faster onset and more predictable effects due to bypassing digestion, but injections can be uncomfortable and require proper technique
Many patients and their healthcare providers would prefer to avoid injections if possible due to the challenges associated with giving/receiving an injection, the complex storage conditions requiring freezing/refrigeration, and the short expiration dating per USP guidelines