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Afferent fibers, which constitute 80% of vagal nerve fibers, transmit mechanical, chemical, and immune signals from the gut to the CNS, whereas efferent fibers (20%) convey central commands to the gut, modulating digestive function and immune responses ( 2.1.2 Bidirectional regulatory mechanisms The bidirectional regulatory mechanisms of the MGBA are manifested through bottomup pathways, whereby gut microbiota influence brain function, and topdown pathways, whereby the CNS modulates gut microecology (Mayer et al., 2022)

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The application of DPP-4i reduces the production of cytokines controlling the proliferation of T lymphocytes (33)