The Pharma Letter reports that obesity drug pipelines are increasingly focused on differentiation through combination pathways, enhanced tolerability and expanded delivery approaches as competition intensifies
The unique function of GPX4 to reduce complex hydroperoxides including phospholipid and cholesterol hydroperoxides, protects biological membranes from the lipid peroxidation chain reaction that otherwise would lead to ferroptosis cell death
This includes genetics and environmental factors such as exposure to pollution and toxins, maternal obesity and diabetes, and advanced parental age
FMT in animal models has been found to reduce the abundance of the Akkermansia genus (in phylum Verrucomicrobia) and increase the abundance of the Prevotella genus (in phylum Bacteroidetes) in gut microbiota (Tankou et al., 2018b), which is in line with findings of decreased gut Akkermansia after probiotic interventions and increased gut Prevotella after first-line disease-modifying treatments and time-restricted eating in MS patients (Jangi et al., 2016
Cell Metab 25(4):927934
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