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In young adult mice on a high-fat diet, MOTS-c also activated muscle AMPK and increased GLUT4 levels, leading to better glucose uptake in muscle and prevention of fat accumulation

Oxytocin also has substantial human data, with meta-analyses quantifying its effects on anxiety and mood

10.1056/NEJM199205143262003 N

GLP-1 drugs have been a valuable treatment for type 2 diabetes for nearly twenty years