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Apparently, glutathionylation of the two class I GRXs by GSSG occurs even at very low GSSG amounts in freshly prepared GSH due to binding of GSSG in a way that favours a trigonal planar bipyramidal transition state 13,15
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Prx5 protects against ferroptosis in bladder cancer, where it is also a potential biomarker [166] , colorectal cancer cells [167] , and cisplatin-induced ferroptosis leading to acute kidney injury [168]
