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Mechanism of Action: Selective muscarinic agonist, resistant to hydrolysis by different cholinesterase isoenzymes The same backbone structure as acetylcholine, but with a methyl side group (Figure 1), which is responsible for its selectivity for muscarinic vs nicotinic receptors (Vardanyan & Hruby, 2006)

Author Contributions Conceptualization, Y.L

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5a,b and Extended Data Fig